CO2 Flash Chromatography

Environmentally Friendly Flash Chromatography with the
NEW eCO2Chrom



Significantly lower solvent consumption

Lower solvent waste


Better performance

Faster separations

Quicker and easier recovery of separated compounds

Increased loading capacity

Greater flexibility in separation columns

 - Use smaller particle sizes

 - Different bonded phases

Faster Concentration


Multiple sample introduction formats:

 - Dry loading onto silica

 - Liquid loading onto disposable column

 - Direct liquid loading onto a

 disposable column

Control of both carbon dioxide pressure and flow rate

Control of modifier solvent flow rate

Disposable separation columns OR

Performance separation columns packed with smaller particles

Automated system with a user friendly

interface and software

Open bed fraction collector

 - Time based fraction collection

 - Peak triggered fraction collection


Download the eCO2 Chrom Flash Chromatography brochure.


Demonstrated Performance

Component mix 8

A chromatogram of an 8 component mix contain a wide variety of compounds including both acidic and basic chemicals.  This chromatogram is an example of separation scope of the instrument and the liquid CO2 separation technique.

This is a demo image

Ibuprofen & ketoprofen

A chromatogram showing the separation of Ibuprofen and Ketoprofen.  These compounds have similar

chemical structures and show the

selectivity that we can achieve with the

eCO2Chrom CO2 Flash instrument.

Ibuprofen & Ketoprofen

Acetaminophen 400µg

A chromatogram of a 400µg acetaminophen sample injected directly onto a cartridge column.  This chromatogram shows the detection sensitivity and most importantly the high degree of baseline stability that we can achieve with the eCO2Chrom CO2 Flash instrument.


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Applied Separations, Inc.     930 Hamilton St., Allentown, PA 18101     610-770-0900